Litchi Faye in the fighting game BlazBlue. One of the other characters (an adorable catgirl) affectionately calls Litchi "the boobie lady"
and this is a character of mine from City of Heroes, her name is Carnal Nature, she's a Thug Mastermind (aka gang leader):
(mind you, I *made* her busty with the customization, but the chest slider goes pretty far
also, there's a couple npc's not designed by players, which are especially busty)