Bob, I'm trying to avoid quoting platitudes, but if reconciliation isn't an option, then lightening your (stress) load is the only way forward. Do you foresee much difficulty getting her out of the business equation?
When I called it splits with my ex, I was also facing financial challenges, not to mention unrelated pressures from the family. It seemed like I was never going to come up for air again. But I did.
If I can do it, you can do it. One stressor at a time.